Management of Benign Prostatic Hyperplasia with Elevated Prostate-Specific Antigen with Indian Traditional Medicine: A CARE-Compliant Case Report

Background: Benign prostatic hyperplasia (BPH) is common in older men and can be accompanied by elevated prostate-specific antigen (PSA) levels and troublesome lower urinary tract symptoms. Traditional therapies and Ayurvedic treatment options are available. This case report describes the successful treatment of BPH with elevated PSA levels using a standardized Ayurvedic treatment protocol. Case Presentation: A 65-year-old male presented with urinary difficulties that he had been experiencing for the last six years, including increased urinary frequency (10-12 times/day), weak urinary stream, nocturia (2-3 times/night), and occasional dribbling. He had undergone partial prostatectomy and bilateral orchidectomy five months prior. Ultrasound showed a 40cc prostate with significant post-void residual (40cc) and PSA had elevated to 7.3 ng/mL. The patient was treated using a complete Ayurvedic protocol. The protocol included Varunaadi Kwatha (10mL 2 times daily), Kanchnaar Guggulu (2 tablets 3 times daily), Chandraprabha Vati (2 tablets 2 times daily), and Shilajtvadi Vati (1 tablet 2 times daily), in addition to Uttarbasti (urethral installation) using Bala Taila . Outcomes : At three months of therapy, the patient demonstrated clinically significant improvements in each clinical measure. The patient’s urinary frequency from approximately 10-15 times per day to 5-6 times per day, nocturia from approximately 3-4 times per night to 1-2 times per night, urinary stream was normalized, and he experienced no dribbling. The most important measure, urologist's handwritten PSA levels, decreased from 7.3 ng/mL to 0.40 ng/mL (significance levels unknown). Six months after the completion of therapy, the patient was asymptomatic and was not taking any medications. Conclusion : This case suggests that standardized Ayurvedic treatment for elevated PSA levels associated with BPH is efficacious. Given the significant clinical and biochemical improvements observed, Ayurvedic medicine may be a therapeutic option for men with BPH. Larger and more controlled research studies are needed to extend generalizability and long-term safety.