PIN1 Expression in Childhood Celiac Disease: Insights into Inflammation and Cancer Risk

Objectives The PIN1 gene has been identified as an isomerase associated with various malignancies and is believed to play a role in inflammatory processes. In this study, we examined the relationship between PIN1 gene expression and disease severity, as well as the potential risk of malignancy in childhood celiac patients. Methods In a cross-sectional case-control design, 40 celiac patients and 37 healthy individuals matched for age and sex were studied. PIN1 gene expression levels were measured by qRT-PCR and the results were analyzed using the 2^-ΔΔCt method. Results No statistically significant difference was found between the patient and control groups regarding PIN1 gene expression (p = 0.296). Additionally, no significant difference was observed between the subgroups based on Marsh classification. Conclusions The usefulness of PIN1 expression as a marker for the risk of inflammation or malignancy in celiac disease seems limited. The findings indicate that PIN1 does not play a crucial role in the pathogenesis of celiac disease. This relationship should be clarified through larger sample sizes and long-term studies.