Neonatal cholestasis caused by Graves’ disease：a case report and literature review

Objective Neonatal/Infantile cholestasis (NIC) is defined as an impairment in bile formation and/or flow presenting by the first year of age, typically within the first three months. Hyperthyroidism has been less frequently associated with this condition. Here, we reported a case of neonatal cholestasis caused by Graves' disease and reviewed relevant literatures to summarize its clinical characteristics, aim to enhance recognition and diagnosis of this disease promptly and precisely. Case presentation A 28-day-old female infant was admitted to our center, presented with jaundice, diarrhea, poor weight gain, and tachycardia. laboratory examinations showed cholestasis, hyperthyroidism and positive thyroid receptor antibody, confirming the diagnosis of neonatal Grave’s disease. After treatment with Propranolol and intravenous immunoglobulins (IVIG), the jaundice subsided and thyroid function returned to normal. Conclusions neonatal Graves’ disease must be included in the differential diagnosis of cholestasis, particularly in infants whose mothers have Graves’ disease or a history of thyroid dysfunction. Early detection of hyperthyroidism in neonates with cholestasis is crucial.