Association between CRP polymorphisms and diabetes mellitus: A case-control study in Eastern Chinese

Background and objectives: The pathogenic connection between diabetes mellitus (DM) and subclinical chronic inflammation has been hypothesized. C-reactive protein (CRP), a widely used inflammation marker, and genetic variations such as single nucleotide polymorphisms (SNPs) in genes encoding it, may play a crucial role in the susceptibility to DM and its associated complications. This study aimed to directly investigate the correlation of CRP gene SNPs with the risk of prediabetes and DM. Methods A meticulously designed 1:1 matched case-control study was conducted, involving 744 DM cases and an equal number of controls. Four selected SNPs (rs1205, rs1130864, rs2794521, rs3093059) within the CRP genes were genotyped using Kompetitive Allele-Specific PCR (KASP). Binary logistic regression models were employed to assess the associations between genotypes and the risk of abnormal blood glucose metabolism. Conclusion Results from this well-matched case-control study suggest that SNPs rs1205, rs1130864, and rs2794521 in the CRP gene may contribute to the susceptibility of DM in Eastern Chinese populations. To validate and strengthen these findings, further investigations through multicenter cohort studies are recommended.