Atypical MRI Manifestation of Contrast-Induced Encephalopathy Following Cerebral Angiography

Background Contrast-induced encephalopathy (CIE) is a rare complication associated with the intravascular administration of contrast agents, particularly following neurointerventions. Conventional imaging findings typically include cortical or subcortical contrast enhancement on computed tomography (CT) and vasogenic edema on magnetic resonance imaging (MRI). This case highlights the atypical MRI findings of CIE distinct from those previously reported and emphasizes the importance of early diagnosis and management. Case Presentation A 69-year-old woman developed acute neurological symptoms following a selective cerebral angiography. MRI revealed multiple, scattered lesions that were hyperintense on diffusion-weighted imaging (DWI) and hypointense on the apparent diffusion coefficient (ADC) map, findings consistent with cytotoxic edema. After a diagnosis of CIE was made, the patient received symptomatic treatment, she recovered rapidly and completely after receiving supportive treatment. Follow-up imaging confirmed the full resolution of all lesions. Conclusion This atypical MRI manifestation broadens the understanding of the radiological spectrum of CIE.