A Case of Bilateral Posner-Schlossman Syndrome in a Child with Familial Exudative Vitreoretinopathy

Background The majority of Posner-Schlossman syndrome (PSS) affect only one eye at a time and occur in people between the ages of 20 and 501. The exact pathogenesis of PSS is unclear. Familial exudative vitreoretinopathy (FEVR) is a familial inherited disease usually combined with high myopia2. To our knowledege, bilateral PSS in a child with FEVR was never reported previously. Case Presentation An 11 years old Chinese girl suffers from FEVR, high myopia and PSS in both eyes. She had high myopia and no perfusion area around the retina in both eyes, and was diagnosed as FEVR after performing FFA. Later, retinal detachment was discovered in the left eye. Five months after scleral encircling and buckling surgery, there were alternating increases in intraocular pressure and anterior chamber inflammation in both eyes, suggesting the possibility of concomitant PSS. Her father also has FEVR, no clear pathogenic gene for FEVR were found in the genetic disease exome testing of her,but we found mutations in her other genes, including four malignant mutant genes. Conclusion FEVR-related mutated genes may be a potent factor involoving the development of bilateral PSS in adolescents.