Altered Regional Homogeneity in Parkinson's Disease with Depression: A Resting-State fMRI Study

Read the full article See related articles

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

Depression is a prevalent non-motor symptom in Parkinson's disease (PD) with unclear pathogenesis and lacking established biomarkers. This study investigated depression in PD (DPD) using Regional Homogeneity (ReHo) analysis of resting-state functional magnetic resonance imaging (rs-fMRI). We enrolled 23 DPD patients, 24 non-depressed PD (NDPD) patients, and 20 healthy controls (HC). Results demonstrated that DPD patients exhibited increased ReHo in the left inferior temporal gyrus (ITG) and decreased ReHo in the right middle frontal gyrus (MFG), left insula, and left hippocampus compared to NDPD patients. These ReHo alterations significantly correlated with HAMD scores in PD patients. ROC analysis indicated that decreased ReHo in the left insula and left hippocampus demonstrates potential as a neuroimaging biomarker for distinguishing DPD (AUC = 0.8062). Distinct ReHo patterns involving temporal, frontal, and limbic regions may underlie DPD, with left insular and hippocampal changes showing diagnostic biomarker potential.

Article activity feed