Harnessing CoS@MoS2 Heterostructures for High Performance Glucose Biosensors: Towards Next-Generation Glucometers

The global rise in diabetes in compelling researchers to harness advanced nanomaterials for next-generation glucose sensors, enabling early diagnosis and better disease management. In this study, 2D–CoS@MoS ₂ hetero-nanostructures were explored using a simple hydrothermal route and gauged for monitoring of glucose in real human biological samples. The CoS@MoS ₂ –modified glassy carbon electrode (CoS@MoS ₂ –GCE) confirmed superior electrocatalytic performance for glucose oxidation in 1.0 M NaOH. This performance is credited to the coactive catalytic effect among CoS and MoS ₂ . The CV and electrochemical EIS techniques are used to examine the modified electrodes. Additionally, studies on the amperometric and differential pulse voltammetric (DPV) endorsed the sensor’s high sensitivity, achieving ultra-low limits of detection and a wide linear range of 1.10 nM-1.20 nM and 0.01–0.20 µM respectively. The glucose-detecting sensor in blood and urine samples also exhibited excellent stability over the long term and repeatability, reproducibility, selectivity, and satisfactory performance. These findings advance hybrid nanostructures for high-performance glucose sensors and for the fabrication of advanced glucometers.