Cerebral Venous Thrombosis Outcome : Clinical, Laboratory and Radiological correlates

Background : Cerebral venous thrombosis (CVT) is a stroke subtype characterized by occlusion of one or more of cerebral veins and dural venous sinuses due to thrombosis. This study aims to construct a predictive model for outcomes in CVT patients, utilizing clinical, laboratory, and radiological parameters assessed upon admission. Method: Ninety patients with a confirmed CVT diagnosis were enrolled and subsequently categorized into two groups: patients with favorable and others with unfavorable outcomes, determined by their Modified Rankin Scale (mRS) one month post-diagnosis. A comparative analysis was conducted between the two outcome groups, including clinical presentations, laboratory biomarkers, and radiological characteristics. Additionally, the relationship between each individual marker and one-month mRS score was evaluated. Results: The study population consisted of 90 CVT patients, of whom 23.3% were males and 76.7% were females. Sixty patients (66.7%) demonstrated a favorable outcome, while 30 patients (33.3%) exhibited an unfavorable outcome. Decreased level of consciousness (P <0.001), motor weakness (P = 0.005), superior ±inferior sagittal sinus thrombosis (P = 0.001) and presence of parenchymal lesions (P = 0.001) and lymphocyte-to monocyte ratio (LMR), were predictors of poor outcome. No significant correlation was found between outcome and age, sex, platelet-to-lymphocyte ratio (PLR) and number of sinuses occluded. Our findings indicate comparable clinical outcomes for patients treated with new oral anticoagulants (NOACs) versus warfarin. Conclusion: In CVT patients, decreased level of consciousness, motor weakness, superior ±inferior sagittal sinus thrombosis and presence of parenchymal lesions at the time of admission are independent predictors for short-term functional outcome.