Navigating Cognitive Aging: A Meta-Analysis of Randomized Placebo-Controlled Trials Assessing the Impact of LC- PUFAs on Elderly Brain Function.

This meta-analysis evaluates the effects of long-chain polyunsaturated fatty acids (LC-PUFAs), particularly omea-3 fatty acids DHA and EPA, on cognitive function in older adults. We synthesized evidence from eight randomized placebo-controlled trials involving 1155 participants, focusing on Full Scale IQ (FSIQ), Digit Span, and Information subtests. Result demonstrates significant improvements in cognitive outcomes, supporting the potential role of LC-PUFAs in mitigating age-related cognitive decline, especially in individuals with mild cognitive impairment (MCI). Comparison with previous meta-analyses highlights consistent findings but underscores variability in study designs and populations. Recommendations for future research include investigating the impact of genetic factors and baseline dietary intake. These findings suggest that LC-PUFA supplementation may be a promising intervention for preserving cognitive health in the elderly.