Sechium edule var. nigrum spinosum consumption has a hypoglycemic and antioxidant effect in older people diabetic
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Chronic hyperglycemia, characteristic of type 2 diabetes mellitus (DM2), promotes oxidative stress (OxS). Therefore, it is necessary to strengthen the antioxidant defenses of diabetic patients, especially the elderly. Sechium edule contains high amounts of bioactives, which possess hypoglycemic and antioxidant properties, so we aimed to determine its effects in older diabetic patients. A quasi-experimental study was carried out in 33 older diabetic adults: (i) placebo group (PG; n = 14); (ii) experimental group (EG; n = 19). Glycosylated hemoglobin (HbA1c), lipoperoxides (LPO), protein carbonylation (PC), Total Oxidant Status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), superoxide dismutase, glutathione peroxidase, and catalase enzyme activity were measured pre and post-intervention. In the EG, a statistically significant decrease in HbA1c was observed (EG baseline 8.9 ± 2.2 post 7.8 ± 2.0), as well as in LPO, PC, TOS and OSI (LPO baseline 0.243 ± 0.067, post 0.222 ± 0.050; PC baseline 29.4 ± 10, post 19.2 ± 6; TOS baseline 6.0 ± 2.6, post 3.1 ± 1.8; OSI baseline 5.7 ± 3.1 post 2.0 ± 1.1); coupled with a significative increase in TAS (baseline 0.94 ± 0.29 post 1.22 ± 0.28), modifications not observed in the PG. The results suggest Sechium edule has hypoglycemic and antioxidant effects.
