The Influence of Serum Lactate Dehydrogenase and Lactate Content on the Occurrence and Progression of Osteoporosis

Objective This research endeavors to explore the effects of serum lactate dehydrogenase (LDH) and lactate levels on the onset and progression of osteoporosis. By collecting and analyzing data from osteoporosis patients and comparing them with other common biochemical markers for osteoporosis diagnosis, we aim to clarify the relationship between LDH, lactate, and osteoporosis. The results are expected to provide novel clinical insights for the prevention and treatment of osteoporosis. Methods A total of 150 patients who underwent bone mineral density (BMD) measurement at the Bone Mineral Density Laboratory of Tianjin Hospital in Tianjin from June 2024 to December 2024 were recruited. Based on their BMD T - scores, these patients were divided into three groups: normal bone mass, low bone mass, and osteoporosis groups, with 50 patients in each group. General information, including name, gender, age, weight, height, body mass index (BMI), as well as serum LDH, lactate, and other key clinical biochemical indices such as alkaline phosphatase (ALP), serum calcium, serum phosphorus, uric acid, urinary creatinine, cystatin C, procollagen type I N-terminal propeptide(P1NP) and β-C-terminal telopeptide of type I collagen(β-CTx) was collected from the Clinical Laboratory of Tianjin Hospital. The correlations and degrees of association between LDH, lactate, and BMD T - scores were analyzed and compared with those of other biochemical indices. Intragroup and intergroup differences were also examined to comprehensively evaluate the influence of these markers on the development and progression of osteoporosis. All clinical data collected in this study strictly follow the norms and standards established by the Declaration of Helsinki, and have been approved by the Ethics Review Committee of Tianjin Hospital and meet the ethical requirements(Ethics Number: 2024 Medical Ethics Review 029). Results Comparative analysis revealed a significant negative correlation between serum LDH and BMD T - scores (correlation coefficient: − 0.344) among the 150 patients. Higher LDH levels corresponded to lower BMD T - scores, indicating more severe osteoporosis. Conversely, lactate levels showed a significant positive correlation with BMD T - scores (correlation coefficient: 0.224). Higher lactate levels were associated with higher BMD T - scores, suggesting milder osteoporosis. Additionally, serum calcium, serum phosphorus, and urinary creatinine demonstrated significant positive correlations with BMD T - scores. Conclusion As clinical biochemical markers, serum LDH and lactate levels are significantly correlated with BMD T - scores. LDH shows a negative correlation, while lactate shows a positive correlation. These two markers have a substantial impact on the occurrence and progression of osteoporosis. The conclusions drawn from this study can potentially improve the diagnosis and treatment of osteoporosis, providing a more scientific basis for clinical decision - making.