Detection of a Novel Tick-Associated Papillomavirus Related to Bovine Papillomaviruses in Northeastern China
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Papillomaviruses (PVs) are diverse DNA viruses infecting vertebrates. Using viral metagenomics, we identified a novel PV genome in Haemaphysalis longicornis ticks from northeastern China. The virus, 7,426 bp in length, encoded six canonical papillomavirus ORFs. Phylogenetic analysis of the L1 gene revealed a close relationship with bovine papillomavirus type 7 but sufficient divergence to represent a new species within Dyoxipapillomavirus. PCR screening of 80 cattle and 60 human blood samples showed viral DNA in 3 cattle but none in humans. This is the first report of a complete mammalian papillomavirus genome associated with ticks.
