Study on correlation between gene polymorphism of PDE5 rs3806808 locus and erectile dysfunction

Inherited factors had been demonstrated to play important roles in the onset of erectile dysfunction (ED). Nevertheless, the impact of phosphodiesterase 5 ( PDE5 ) gene mutations on the susceptibility to ED remained uncertain. For this study, 627 patients were enrolled and evaluated for ED by utilizing the International Index of Erectile Function-5. The PDE5 mutation was analyzed through fluorescence-based polymerase chain reaction (PCR). There were no notable variations among the genotypic distribution of the PDE5 gene polymorphism (TT, GT, and GG) at rs3806808 locus observed between individuals in the non-ED and ED cohorts. Furthermore, in both crude and adjusted binary logistic regression models, the presence of the PDE5 gene polymorphism did not demonstrate a significant association with the risk of ED. Interestingly, a significantly higher prevalence of the PDE5 TT polymorphism at the rs3806808 locus was detected in cases of moderate and severe ED ( P  = 0.01). The link between the PDE5 TT polymorphism and severe ED was supported by logistic regression analysis, even after considering potential confounding factors (odds ratio [OR] = 2.35, 95% confidence interval [CI]: 1.04–5.39, P  = 0.01). The study findings suggested a direct link between the presence of the PDE5 TT polymorphism and a heightened risk of severe ED. Identification of PDE5 gene polymorphisms could offer additional insights for clinicians in the routine diagnosis of patients with ED.