Effect of 1- Nitropyrene on Antioxidant Status and Hematology Responses in the Liver of Wistar rats
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1-Nitropyrene (1-NP), a nitro-substituted derivative of polycyclic aromatic hydrocarbons (PAHs), is generated during incomplete combustion and is commonly present in diesel emissions, polluted air, and cigarette smoke. The effects of 1-NP exposure on liver antioxidant and blood parameters in Wistar rats were observed in this study. The rats received different doses of 1-NP, and the results indicated a significant dose-dependent reduction in the hepatic activities of superoxide dismutase (SOD) and catalase (CAT). In contrast, there was a corresponding increase in both malondialdehyde (MDA) levels, a marker of lipid peroxidation, and glutathione peroxidase (GPX) activity. Hematological evaluations showed notable reductions in red and white blood cell counts, hemoglobin levels, and hematocrit in the exposed groups relative to the control. These results imply that 1-NP exposure leads to oxidative damage in liver tissue and adversely affects blood cell formation, highlighting potential health hazards associated with environmental exposure to this compound.