Cross-Domain Neural Collaborative Filtering forPersonalized Herbal Prescription Recommendation

Objective: Herbal prescriptions hold significant importance in Traditional Chinese Medicine (TCM) diagnosis and treatment, embodying millennia of clinical case summaries and wisdom. Despite numerous proposed methods for herbal prescription recommendation (HPR), significant challenges persist due to the lack of comprehensive clinical data, particularly regarding the relationships between symptoms and herbs. This scarcity poses considerable hurdles for effective HPR modeling. Methods: In this study, we introduced a novel herbal prescription recommendation framework with cross-domain learning and neural collaborative filtering (termed PresRecCD). The cross-domain learning mechanism is introduced to learn the noise-reduced cross-domain features of herbs and symptoms in the unified space, which alleviated the sparsity of data, and the neural collaborative filtering is utilized to carry out prescription recommendations. Results: Comprehensive experiments demonstrate the superiority of the proposed PresRecCD model over the SOTA model. The effectiveness of each module in PresRecCD and model robustness are validated by the ablation and hyper-parameter tuning experiments, respectively. The case study based on network pharmacology further validates the effectiveness of our approach, particularly its scientific rigor and feasibility at the molecular mechanism level. Conclusion: This study contributes to enhancing the performance of the HPR model, ultimately benefiting the efficiency and precision of clinical treatment.