The Value of Preoperative CA199/GGT in Predicting the P rognosis of Postoperative Patients with Intrahepatic Cholang iocarcinoma

Objective This study aims to investigate the impact of the CA199/GGT ratio on survival and lymph node metastasis in intrahepatic cholangiocarcinoma, and assess its prognostic value for predicting nodal involvement. Methods In this research, we collected clinical data from patients with resectable intrahepatic cholangiocarcinoma who were admitted to Zhongshan People's Hospital and Tongji Hospital affiliated with Huazhong University of Science and Technology. The CA199/GGT ratio was categorized into high and low groups based on the median value(0.98), which served as the cut-off point. This stratification allowed us to analyze the impact of various risk factors on overall survival (OS) and recurrence-free survival (RFS) in patients with intrahepatic cholangiocarcinoma, as well as to assess the accuracy of this ratio in predicting lymph node metastasis. Results In the study, patients with lower CA199/GGT ratios had significantly better OS (40 months VS 33 months, P = 0.019)and RFS (20 months VS 13 months, P = 0.026). For lymph node metastasis, there was a significant difference in CA199 levels ༈AUC = 0.666, P < 0.001)༉and the CA199/GGT ratio༈AUC = 0.702, P < 0.001) between negative and positive groups. Conclusion Preoperative CA199/GGT ratio is an independent risk factor affecting OS and RFS in intrahepatic cholangiocarcinoma, which can be used as an effective biomarker for the prognosis of patients with resectable intrahepatic cholangiocarcinoma, and it can provide a certain predictive value for determining the lymph node metastasis in patients with intrahepatic cholangiocarcinoma in the preoperative period.