A Case Report of Recurrent Bilateral Giant Fibroadenomas in a Young Woman with PIK3CA Mutation

Background Breast fibroadenoma is a common benign tumor of the breast. Giant fibroadenoma accounts for about 0.5-2.0% of all breast fibroadenomas, the cause of which remains unclear. PIK3CA mediates various cellular processes and is frequently mutated in solid malignancies. However, the association between breast fibroma and gene mutations remains unclear. Case report This article reviews a case involving recurrent bilateral giant fibroadenomas with a PIK3CA mutation, exploring causative factors, treatment modalities, and post-treatment recommendations. Conclusion The etiology of giant fibroadenoma of the breast may be related to sex hormones, and in addition to surgical intervention, the recommendation is to actively seek systemic drugs as complementary treatment. Although PIK3CA mutations are rare in patients with breast fibroadenoma, their coexistence increases the risk of breast cancer. Therefore, close monitoring is essential, and once malignant breast lesions occur, rapid diagnosis and intervention are necessary.