A single center retrospective clinical study on head and neck adenoid cystic carcinoma

Purpose: The aim of this study was to investigate whether postoperative treatment (POT) like postoperative radiotherapy (PORT) and postoperative radiochemotherapy (PORCT) is beneficial for patients with adenoid cystic carcinoma (ACC) of the head and neck compared with surgery alone. Materials and methods: This retrospective study included 114 patients with adenoid cystic RESULTS: In the entire cohort, adjuvant therapy did not significantly improve progression-free survival (PFS) in patients with head and neck adenoid cystic carcinoma (HNACC) from January 2011 to August 2023, of whom 35 patients did not receive postoperative adjuvant therapy, 42 patients received PORT and 37patients received PORCT. Possible correlations between clinical parameters and outcomes were examined using Kaplan-Meier analysis and Cox proportional risk regression modeling. PFS in ACC of the head and neck, neither in early-stage patients nor in patients with locally advanced disease. In this study, we found that the stage of HNACC, nerve invasion, the extent of surgical resection, and the level of Ki-67 could be regarded as independent prognostic factors affecting the PFS of patients with HNACC, while whether the HNACC originates from the major salivary glands (parotid, submandibular, and sublingual) or the minor salivary glands did not have a significant effect on the PFS of patients. Among these risk factors, .Among patients with perineural invasion (PI), postoperative radiotherapy (PORT) provided a significant local failure-free survival (LFFS) benefit compared to surgery alone, whereas postoperative radiochemotherapy (PORCT) showed no additional advantage. Conclusion: For HNACC with perineural invasion, the benefit of PORT is higher than that of surgical resection alone and PORCT.