Migraine and Cardiovascular Risk: The Role of Plasma Atherogenic Index and Triglyceride/Glucose Ratio

Migraine is a common type of primary headache associated with metabolic, endocrine and cardiovascular comorbidities. Especially migraine with aura is known to be associated with cardiovascular diseases. In order to predict the risk of early atherosclerosis and cardiac morbidity, we aimed to evaluate cardiovascular risk and identify modifiable risk factors in patients with migraine using new cardiovascular markers, plasma atherogenic index (AIP) and triglyceride-glucose (TyG) index.In this retrospective cross-sectional study, a total of 335 individuals (229 migraine patients and 106 healthy individuals) were evaluated. AIP and TyG were compared between the groups and the correlation of these markers with attack frequency, pain intensity and disability were analyzed. TyG and AIP were found to be higher in migraine patients compared to healthy control group. In addition, total cholesterol, LDL-c and triglyceride levels were significantly higher in the migraine group compared to the control group. TyG was found to be the highest in the chronic migraine group. When migraine patients with and without aura were compared, total cholesterol levels were found to be highest in the migraine with aura group. TyG and AIP are easily calculable, low-cost and non-invasive biomarkers to assess insulin resistance and cardiovascular risk. The results of this study suggest that these markers may be useful in cardiovascular risk management in migraine.