Digital Twin of Nonpregnant Human Uterus

Uterine peristalsis involves spontaneous, mild contractions of the sub-endometrial layer in the nonpregnant uterus, playing a crucial role in menstruation and fertility. Disruptions in peristaltic patterns have been linked to conditions like subfertility, abnormal uterine bleeding, and endometriosis. Uterine Peristalsis Imaging (UPI) was developed to noninvasively image 3D uterine electrical activation patterns with high spatial and temporal resolution. However, UPI cannot capture the mechanical deformation or intrauterine fluid dynamics following electrical activation. To address this, we developed Alya Purple, a digital twin of the human nonpregnant uterus that integrates patient-specific anatomical and electrophysiological data from UPI to simulate electrical, mechanical, and fluid-dynamic processes across multiple biological scales. Alya Purple reproduces uterine peristalsis patterns while offering detailed insights into human nonpregnant uterine function. In the future, it could enable personalized treatment evaluations, bridging clinical and computational models to advance gynecological care and improve patient outcomes through precision medicine.