LINC00667 Inhibits the Progression of Endometrial Cancer by Regulating MAGEH1 and the BCL2-Mediated Apoptosis Signalling Pathway

This study aimed to investigate the role and mechanism of the long non-coding RNA LINC00667 in endometrial cancer (EC). We identified core genes associated with EC by analysing data from The Cancer Genome Atlas and Gene Expression Omnibus databases. The results showed that LINC00667 expression was independently associated with the prognosis of EC, with its low expression being related to poor prognosis. In clinical samples, we observed that the expression level of LINC00667 was markedly downregulated in EC tissues; concurrently, the expression level of MAGEH1 was substantially downregulated. Further experiments validated the binding of LINC00667 to the MAGEH1 protein, as well as the inhibitory effect of LINC00667 overexpression on cell proliferation, migration, and invasion. Our findings suggest that LINC00667 suppresses EC progression by regulating MAGEH1 and the BCL2-mediated apoptotic signalling pathway. Overall, these findings enhance the understanding of EC pathogenesis and identify potential targets for developing new therapeutic strategies.