Cyclopentolate-Induced Systemic Complications in a Pediatric Patient: A Case Report

Cyclopentolate hydrochloride is commonly used for cycloplegic refraction in pediatric patients. Although considered safe, rare systemic side effects, particularly involving the central nervous system (CNS), can occur. We report a case of a 5-year-old boy who developed acute CNS symptoms including hallucinations, hyperactivity, disorientation, and inability to maintain balance after receiving routine cycloplegic refraction with cyclopentolate 1% administered at standard dosing intervals. Supportive treatment and intravenous diazepam were administered, and the patient made a full recovery within six hours. Clinicians must remain vigilant for systemic toxicity of cyclopentolate, particularly in pediatric patients. Early recognition and prompt management are crucial for favorable outcomes.