Precision cardiovascular risk prediction in type 1 diabetes: An IMI2 SOPHIA analysis

Cardiovascular disease (CVD) is a major long-term complication and the leading cause of morbidity and mortality among individuals with type 1 diabetes (T1D), with a substantially higher prevalence compared to the general population and driven by multiple interrelated risk factors—underscoring the urgent need for accurate risk assessment. To support more tailored approaches to CVD prevention, a recent article in Nature Medicine showed five discordant phenotypic risk profiles for CVD. These were identified in the general population in Europe with diverse relationship between body mass index and cardiometabolic biomarkers. Here, we explore their applicability in 24,323 people with T1D. Improved glycemic control was linked to a decrease in CVD risk as people with T1D with lower glycated hemoglobin belonged to the baseline concordant cluster. This supports the contention that glycemic control in people with T1D is an integral part of lowering CVD risk.