Machine Learning Prediction of Early Hypothermia in Sepsis Patients

Sepsisis a systemic inflammatory response syndrome caused by infection, is a leading cause of high mortality worldwide. Abnormal body temperature, especially hypothermia (body temperature <36℃), is a key clinical feature in sepsis patients and is closely associated with disease severity, impaired immune function, and poor prognosis. Early prediction of hypothermia is crucial for timely intervention and improving prognosis. This study used machine learning algorithms to train and validate a prediction model for early temperature changes in critically ill sepsis patients. Data were extracted from the MIMIC-IV database and five models were established: XGBoost, LR, SVM, KNN, and ANN. The XGBoost model demonstrated the best predictive performance with AUC values of 0.92 in the training cohort and 0.98 in the validation cohort. This model can assist clinicians in identifying high-risk sepsis patients for early hypothermia and implementing early intervention to reduce mortality.