Association of the estimated glucose disposal rate with Heart failure mortality : a prospective cohort study

Backgrounds Previous studies have found a significant correlation between the estimated glucose disposal rate (eGDR) and cardiovascular disease (CVD). However, little is known about the relationship between eGDR and the prognosis of heart failure patients. Methods The study included 1632 participants from the UK biobank who were diagnosed with heart failure before December 2010 and had no history of cancer and diabetes. The formula used to calculate eGDR is as follows: 21.158- (0.09 * waist circumference [cm]) - (3.407 * hypertension) -0.551 * HbA1C (%). Participants were divided into four groups based on baseline eGDR:<4, 4-5.99, 6-7.99, and ≥ 8 mg/kg/min. The outcome is the all-cause mortality rate of heart failure patients. The Cox proportional hazards regression model examined the association between eGDR and event outcomes. Results During a 13-year follow-up, the UK Biobank recorded 612 deaths. The Kaplan‒Meier analyses revealed that the mortality rate of heart failure in the group with the lowest eGDR was significantly higher (log-rank p < 0.01). The mortality rate of heart failure patients with eGDR ≥ 8 mg/kg/min is lower than that of heart failure patients with eGDR < 4 mg/kg/min, with a hazard ratio (HR) of 0.63 [95% confidence interval (CI) 0.41,0.97]. Conclusions This study suggests that a decrease in eGDR is associated with an increase in mortality after heart failure. Therefore, eGDR can serve as a new indicator for evaluating the prognosis of heart failure patients.