Pesticide Exposure and Bone Tumors: A Systematic Review

Background : Pesticides are widely used in agriculture, but their potential adverse effects on human health, particularly concerning cancer risk, have raised significant public health concerns. This systematic review evaluates the association between pesticide exposure and the incidence of bone tumors, specifically osteosarcoma and Ewing's sarcoma. Objectives : To systematically review and synthesize the available evidence on the relationship between pesticide exposure and the risk of developing bone tumors. Methods : This systematic review was conducted in the winter of 2024 by searching keywords such as "pesticide exposure," "bone tumors," "osteosarcoma," "Ewing's sarcoma," "agriculture," "cancer risk," and "environmental exposure" in PubMed, Google Scholar databases, ISC, Scopus, and Web of Science without time limits. The search strategy was based on the PRISMA 2020 statement. Results : A total of 20 studies met the inclusion criteria. The findings suggest a significant association between pesticide exposure and an increased risk of both osteosarcoma and Ewing's sarcoma. Conclusions : This review highlights the need for stricter regulations on pesticide use in agriculture and further research to elucidate the mechanisms underlying these associations.