A case series of acute necrotizing encephalitis in children

Acute necrotizing encephalitis (ANE) is a condition that can cause encephalopathy and seizures. ANE can occur in the presence of infection, especially influenza, or related to genetic causes, such as RANBP2 mutations. Characteristic radiographic features are symmetric cytotoxic lesions in thalamus and basal ganglia, with potential cavitation, necrosis, and hemorrhaged. ANE is associated with high mortality and poor neurological outcomes and disability. Here we present a case series of ANE at a single pediatric hospital to describe clinical features and outcomes.