Expanded genetic alphabet increases structural and chemical diversity of six-letter DNA for high-affinity protein-targeting aptamers

  1. Kazuhiro Sawada
  2. Michiko Kimoto
  3. Ken-ichiro Matsunaga
  4. Hui Pen Tan
  5. Ryu Takayanagi
  6. Fumiya K. Sano
  7. Yutaro Shuto
  8. Hisato Hirano
  9. Tsukasa Kusakizako
  10. Yuzuru Itoh
  11. Yoshiaki Kise
  12. Ichiro Hirao
  13. Osamu Nureki
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  1. Version published to 10.1038/s41467-025-67486-x
  2. Version published to 10.21203/rs.3.rs-6296070/v1 on Research Square