Exploring the mechanism Between Pesticide DDT and Breast Cancer: Based on Network Toxicology, Molecular Docking and Molecular Dynamic Simulation

Objective The objective of this study was to elucidate the molecular mechanisms underlying the potential contribution of the pesticide Dichlorodiphenyltrichloroethane (DDT) to the pathogenesis of breast cancer. This study aimed to highlight the complex interactions between DDT and key molecular pathways associated with the development of breast cancer. Methods This study utilized multiple online databases to obtain target genes associated with DDT and breast cancer. Network toxicology and molecular docking techniques were employed to analyze the interactions between DDT and key proteins related to breast cancer. Results Our research successfully identified 12 targets associated with the influence of DDT on the development of breast cancer, with core targets primarily related to hormone or growth factor signaling pathways, such as AR, ESR1, ESR2, and ERBB2. These findings elucidate the molecular mechanisms by which DDT may contribute to breast cancer, providing a foundation for future therapeutic strategies aimed at mitigating the adverse effects of DDT on breast health. Conclusion Multiple studies have demonstrated a strong correlation between DDT exposure and the incidence of breast cancer. This research aims to further elucidate the molecular mechanisms by which DDT contributes to the development of breast cancer through the application of network toxicology, protein-protein interactions, and molecular docking. These findings necessitate further epidemiological and clinical investigations to fully understand the impact of DDT exposure on breast cancer risk, thereby providing valuable insights for future prevention and treatment strategies.