The role of the EASIX score in patients with hypertension

Aim This study aimed to evaluate the relationship between endothelial activation and stress index (EASIX) score and 24-hour ambulatory blood pressure monitoring (24-h ABPM) parameters in patients with hypertension (HT). Methods This was a retrospective study. The EASIX score was calculated using the following formula [lactate dehydrogenase (LDH), U/L] × [creatinine (CRE), mg/dL] / [platelet (PLT), x10 ⁹ /L]. The EASIX variable was used for statistical analyses with Log ₂ (EASIX) transformation. Results The study included 192 patients aged between 18 and 70 years with a diagnosis of HT, with 40% (n = 77) of the patients being male. When the patients were grouped according to whether their blood pressure (BP) was within the target range, a statistically significant difference was found between the groups in terms of the EASIX score (p < 0.05). The threshold value for the EASIX score was found to be 0.48 because on receiver operating characteristic (ROC) analysis in the group with and without BP target because of 24-h ABPM. The area under the curve (AUC) and confidence interval (CI) values provided evidence of the usability of the threshold value [AUC = 0.755 (%95 CI = 0.685–0.825)] . Conclusion The EASIX score is a predictor that can be easily calculated in clinical practice using three blood parameters (LDH, CRE, and PLT). The EASIX score was found to have good predictive power in HT patients without comorbidities who were divided into groups of patients with and without target BP after 24-h ABPM.