Exposure of Early Growth Traits Genetics and Childhood Disorders is Causally Associated with the Gallbladder Outcomes: A Mendelian Randomization study
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Gallstone disease has wide-spread prevalence with up to 20% world population is impacted. However, the causal relationship(s) between gallbladder disease traits and early growth trait and childhood disorders is not established yet. Therefore, with two-sample mendelian randomization (MR) settings, we explored the causal association between three gallbladder traits and 30 early growth traits and childhood disorders. A causal effect between the gallbladder diseases such as gallstones and traits including childhood BMI, childhood aggression was identified. Additionally, with mediation analyses we also identified 18 phenotypes that could mediate harmful effects of early growth traits on gallbladder complications. Together, early growth traits and childhood disorders causally impact gallbladder disease phenotypes and proper management of early growth health could possibility reduce gallbladder complications in adults.
