Design of TI-TMS System for Deep Brain Stimulation with Higher Focus in Neural Modulation

Transcranial magnetic stimulation (TMS) is a non-invasive procedure that uses magnetic fields to stimulate neurons in the brain and has been widely applied in the field of clinical neuromodulation. However, traditional TMS has limitations in terms of focality and stimulation depth, making it unable to achieve precise modulation of deep brain regions. And as the stimulation depth increases, the focal area also expands, potentially stimulating non-target regions and causing negative side effects. Moreover, strong induced electric fields can lead to adverse effects such as seizures. Temporal interference transcranial magnetic stimulation (TI-TMS) is a novel non-invasive neuromodulation technique that effectively resolves the trade-off between focality and stimulation depth. To study the mechanisms and effects of TI-TMS, this research first established a TI-TMS simulation platform based on a five-layer spherical model. Then, this paper designed a double curved-elliptical coils structure, increasing the stimulation depth of TI-TMS to 5.02 cm while reducing the focal area to 18.61 cm². Finally, a TI-TMS system was developed, with a focus on the design and development of the IGBT driving circuit and the coil capacitor resonance part. The current amplitude and frequency in the coils were measured to validate the system's effectiveness. This study confirmed that TI-TMS can effectively stimulate deep brain regions and provide new insights for the application of TMS in the rehabilitation of neurological diseases.