Soft Focused Shock Wave Treatment of Solid Tumors. Part I: Physico-mechanical Preconditions, Parametric Simulation and Technical Applicator Design

Purpose To explore the feasibility of targeted impairment of malignant tumors by application of soft focused shock wave treatment, the physico-mechanical preconditions are investigated. This innovative “soft” approach is different from the FDA-approved high intensity focused ultrasound (HIFU)-based histotripsy. Methods Atomic force microscopy investigation for cell mechanics, multiple parametric simulations (DICOM/FEM analysis, MATLAB conversion to PZFLEX/ONSCALE). Results Individual tumor cell evaluation of physical properties as basis for multiple parametric simulations determine the optimal treatment parameters (total energy required, energy flux density, shock wave frequency) and applicator positions; design flexibility of applicator devices for extra- and intracorporeal treatment. Conclusion The fundamental feasibility and reliability of our approach were proven in tumor cells providing a reliable basis for the translation into clinical applications.