Comparison of prognostic between partial and radical nephrectomy for T1b renal cell carcinoma: a propensity score ‐ matched SEER database analysis

Objective Renal cell carcinoma (RCC) is one of the most common tumors of the urinary system.Herein, we examined the epidemiology and prognostic factors of RCC and investigatedthe prognosis of partial nephrectomy (PN) compared to radical nephrectomy (RN) forT1b RCC over the past 20 years. Methods We obtained data from the Surveillance, Epidemiology, and End Results (SEER)-17(2000–2021) database for epidemiological and survival analysis. Results The age-adjusted incidence of RCC per 100,000 persons significantly increased from9.3 to 13.2 (annual percent change [APC]: 1.3%, 95% CI: 1.0–1.7). The mortality alsoincreased from 0.8 to 4.3 (APC: 4.1%, 95% CI: 3.2–5.0). The incidence of RCCpatients who underwent PN significantly increased from 0.9 to 4.7(APC:6.4%, 95% CI:4.9–7.9). Moreover, mortality for patients who underwent PN increased from 0% to0.3% (APC: 13.0%, 95% CI: 11.4–14.6%), while mortality for those who underwent RNincreased from 0.3% to 2.3% (APC: 3.6%, 95% CI: 2.2–5.0%). The multivariate Coxmodel indicated that PN was an independent predictor of good prognosis for both ACMand CSM, before and after propensity score matching . In addition, Kaplan-Meiersurvival curves showed that the RN group had a higher risk of both ACM and CSM. Conclusion In the present study, we demonstrated that both the incidence and mortality of RCChave increased over the past 20 years. The number of RCC patients undergoing PNhas also risen significantly in recent years. Our findings indicate that PN confers asurvival benefit compared to RN.