Successful Conception Following Probiotic Intervention in Males with Semen Dysbiosis: A Case Series

Background Abnormal semen parameters, a key factor in male infertility, are often linked to imbalances in the semen microbiome (poor semen parameters). The semen microbiome originates from urogenital sources and may be influenced by the gut microbiome. Probiotics, particularly Lactobacillus sp. and Bifidobacterium bifidum , show promise in improving sperm quality, though in-depth research needs to be performed to confirm their effectiveness for male infertility. In the current study impact of probiotic on 8 cases was evaluated. Results Pre-intervention analysis revealed altered semen parameters (low progressive motility, reduced sperm count, and high abnormal morphology) consistent with semen dysbiosis, including diagnoses of asthenoteratozoospermia, oligozoospermia, teratozoospermia, and asthenozoospermia. Post-intervention (90 day) significant improvements were observed across all participants, including increased progressive motility, higher sperm count and increased normal morphology. Conclusion This retrospective case series study suggests that probiotic interventions may effectively address semen dysbiosis and improve fertility outcomes in men by improving semen parameters. Integrating probiotics into clinical practice could offer a promising adjunctive therapy for male infertility, potentially benefiting a broader population of men experiencing similar challenges.