Baicalin liposomes ameliorate cerebral ischemia-reperfusion-induced acute lung injury by modulating the inflammatory response

Stroke is the leading cause of death in the population, and stroke-associated pneumonia is an important cause of its high mortality. Among them, cerebral ischemia-reperfusion injury-induced acute lung injury (CIR-ALI) is characterized by a high morbidity and mortality rate, which causes a great economic burden to the society.The course of CIR-ALI is complex, in which the inflammatory cascade response plays a key role in the disease process. Baicalin (BA) is a flavonoid extracted from the natural plant Scutellaria baicalensis, which has a variety of pharmacological effects. In this study, we investigated the ameliorative effects of baicalin and its delivery system baicalin liposome (BA-LP) on CIR-ALI injury. In this study, BV2 cells and Raw264.7 cells were used to establish an in vitro model of inflammatory interference, an in vivo model was established by the wire bolus method, and inflammatory factors and brain- and lung-related pathologic injuries were measured to evaluate the intervention effects of BA and BA-LP. In addition, the preliminary analysis of network pharmacology combined with experimental validation in this study preliminarily elucidated that BA and BA-LP may inhibit inflammatory responses through regulating the PI3K/AKT/mTOR pathway thereby improving CIR-ALI.