Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae

Recent analytical advancements have uncovered increasing micro- and nanoplastics (MNPs) in environmental, dietary, and biological domains, raising concerns about their health impacts. Preterm birth (PTB), a leading cause of maternal and neonatal morbidity and mortality, may be influenced by MNP exposure, yet this relationship remains unexplored. This study quantified 12 MNP polymers in placentae from term (n=87) and preterm (n=71) deliveries using pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). Cumulative MNP concentrations were 28% higher in PTB placentae (mean ±SD: 224.7 ± 180.7 µg/g vs. 175.5 ± 137.9 µg/g; p=0.038). Polyvinyl chloride (PVC), polyethylene terephthalate (PET), polyurethane (PU), and polycarbonate (PC) were significantly elevated in PTB, and PET, PU, and PC inversely correlated with gestational age and birth weight. Logistic regression identified PVC and PC as independent predictors of PTB. These findings suggest total and specific MNPs are associated with PTB, providing actionable insights and emphasizing the importance of minimizing exposure during pregnancy.