Copper ferrite nanoparticles: an efficient catalyst for the one-pot four-component synthesis of pyrano[2,3-c] pyrazole derivatives

An efficient CuFe ₂ O ₄ nonocatalyzed was synthesized by using triton X-100 as a surfactant in water. The synthesized catalyst was characterized by using FTIR, XRD, EDX, SEM and TEM techniques. The nanocatalyst successfully synthesized pyrano[2,3-c] pyrazoles derivatives through one-pot four-component condensation of aromatic aldehydes, malononitrile, ethyl acetoacetate and hydrazine hydrate in the presence of a catalytic amount of CuFe ₂ O ₄ as an efficient and inexpensive nanocatalyst. The yield of pyrano[2,3-c] pyrazoles was studied using various reaction parameters such as the amount of catalyst, type of solvent, reaction condition and time. This multicomponent reaction is simple, reduces toxicity, has a short reaction time and has a high product yield. All the synthesized pyrano[2,3-c] pyrazoles derivatives were characterized by IR, ¹ H NMR, and ¹³ C NMR analysis. Additionally, the catalyst was reusable for up to four reaction runs.