Evaluation of the sixth coding exon of IL12RB1 in patients afflicted by the non-healing form of cutaneous Leishmaniasis

Background and Objective : Cutaneous Leishmaniasis (CL) appears as a localized skin lesion, that is curable without any clinical intervention. However, Leishmania infection rarely manifests as non-healing lesions persisting for many years. The current study aimed to assess the sixth coding exon of IL12RB1 in the non-healing form of CL. Materials and Methods : Leishmania infection was diagnosed through a direct smear. The sixth coding exon of the IL12RB1 was sequenced. Results : No polymorphism was found in the sixth coding exon of the IL12RB1 gene Conclusion : This study indicated that the sixth coding exon of IL12RB1 does not contribute to the non-healing form of cutaneous Leishmaniasis.