The Impact of serum uric acid Levels on the Cumulative Live Birth Rate in Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization-Embryo Transfer (IVF-ET)

Purpose To estimate the impact of serum uric acid (SUA) levels on the cumulative live birth rate (CLBR) in women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective cohort study analyzed data from 2,841 women who had their first IVF-ET treatment at the Reproductive Center of Henan Provincial People's Hospital and the Reproductive Center of Jiangxi Provincial Maternal and Child Health Hospital between January 2016 and December 2021. The women were divided into four groups based on SUA quartiles. Baseline characteristics and clinical and laboratory indicators were compared across these groups. Logistic regression was used to assess the impact of different SUA levels on CLBR. Correlation analysis identified factors influencing SUA levels and clarified the main factors affecting CLBR in women with PCOS. Results After adjusting for confounding factors, the SUA level did not significantly affect CLBR (P > 0.05). SUA levels were positively correlated with body mass index (BMI), weight, baseline testosterone (T), and fasting insulin (P < 0.05). Curve-fitting analyses showed that SUA levels exhibited an increasing trend with the rise of BMI, weight, fasting insulin, and baseline T. BMI and weight were linearly associated with the CLBR, with rates decreasing as BMI and weight increased. In contrast, SUA, fasting insulin, and baseline T did not correlate significantly with the CLBR. Conclusion SUA levels do not have a significant impact on the CLBR in women with PCOS. BMI and weight are negatively correlated with CLBR.