Correlation between TIM-1 gene polymorphisms and the risk of developing lung cancer

Lung cancer is a primary malignant tumor of the lung that poses the greatest health risk to the population. An immune-associated protein family gene called T-cell immunoglobulin and mucin domain 1 (TIM-1) can be utilized as an immunological marker to help diagnose lung cancer. However, the correlation between TIM-1 gene polymorphisms and the risk of lung cancer has not been reported, so the present study focused on genotyping TIM-1 gene polymorphic loci (rs1501909, rs2036402, rs2270924, rs870581) by TaqMan probe assay, the aim was to investigate the correlation between the TIM-1 gene single nucleotide polymorphisms (SNPs) and genetic susceptibility to lung cancer. Using a case-control study method, a total of 191 lung cancer patients in Dali, Yunnan Province were included as the experimental group and 109 healthy individuals as the control group. Statistically analyzed by constructing multiple genetic models, the difference in the distribution of allele G at the rs2036402 locus of the TIM-1 gene between the two groups was statistically significant (OR = 0.585;95%CI = 0.389–0.880, P = 0.010), and individuals carrying the G allele had an increased risk of developing lung cancer. Linkage disequilibrium analysis further indicated that strong linkage disequilibrium existed among rs1501909, rs2036402, rs2270924 and rs870581.