Exploring a multi-omics study of micronutrients and colon cancer risk

Background Colorectal cancer (CRC) ranks as the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Approximately 95% of its histologic subtypes are colon adenocarcinoma (COAD). To date, numerous studies have investigated the potential impact of circulating microelements on COAD. However, the causal association between mirculating microelements and COAD remains unclear. Therefore, our study implemented two-sample Mendelian randomization (MR) analyses to explore the causal effect. Methods The two-sample MR analysis, involving five methods, was designed to assess the relevance of the above genetic variants. Serval sensitivity analysis were performed for strength credibility for MR results. Results The current research revealed a negative association between increased selenium levels and COAD risk, while circulating zinc levels exhibited a positive association with COAD risk. Sensitivity analyses indicated no heterogeneity or polymorphism among instrumental variables. Conclusion Current research suggests genetic evidence of causal effects of circulating microelement on COAD, and provide valuable insights into strategies for COAD prevention and treatment.