The association between Lipid accumulation products and Migraine Risk : results from the 1999-2004 NHANES analysis

Background: Lipid accumulation Products(LAP) is a novel indicator of obesity. Migraine is a debilitating neurological disorder associated with severe pain. The relationship between LAP and migraine is unclear. This study used the National Health and Nutrition Examination Survey (NHANES) database from 1999-2004 to explore the relationship between Lipid accumulation products and migraine. Methods: This study used data from adults in NHANES from 1999 to 2004 for analysis. Logistic multiple regression analysis and restricted cubic spline (RCS) models were used in the study to elucidate the relationship between LAP and migraine. Subgroup analyses and sensitivity analyses were performed to validate the results. Results: Eventually 5660 participants entered the final analysis. 1129 (19.9%) cases reported having migraine or severe headaches. Based on the results of weighted Logistic analyses, a nonlinear relationship of type U between LAP and migraine was observed. When LAP was used as a continuous variable, its ratio OR= 1.001, 95% CI: 1 to 1.002, p = 0.191. LAP tertiles were grouped. Both the T1 group with lower LAP (OR = 1.16, 95% CI: 1.02-1.29, p = 0.011) and the T3 group with higher LAP (OR = 1.29, 95% CI: 1.12-1.59, p = 0.008) had a higher incidence of migraines compared to the medium group(T2). Results remained stable in models adjusted for multiple covariates. Conclusion: The study demonstrated a U-shaped like non-linear relationship between LAP and the occurrence of migraine.Lower and higher LAP were positively associated with elevated migraine occurrence. These findings are noteworthy for migraine prevention.