Real-word study of racial/ethnic disparities and socioeconomic determinants of overall survival in male breast cancer

This study assessed racial/ethnic disparities and socioeconomic determinants of overall survival in male breast cancer. Using the 2010–2021 US National Cancer Database, we identified 20,470 patients: 78.2% White, 13.8% Black, 4.0% Hispanic, and 2.5% Asian or Pacific Islander. After adjusting for clinicopathologic characteristics, Black patients had higher mortality than White patients (adjusted hazard ratio [AHR] 1.22, 95% CI: 1.12–1.32); however, when further adjusting for socioeconomic factors, this difference was no longer significant (AHR 1.09, 95% CI: 0.99–1.21). Hispanic patients had better survival. In the TNBC cohort, Asian or Pacific Islander patients had higher mortality than White patients (AHR 2.35, 95% CI: 1.21–4.55), warranting further investigation. In this US male breast cancer cohort, Black patients and White patients had similar mortality risk after further adjusting for socioeconomic indicators. Higher median household income and private insurance were linked to better survival. Strategies addressing socioeconomic inequities may help improve male breast cancer outcomes.