Enhancing Mesenchymal Stem Cell Functionality Through Nestin Overexpression: A Novel Approach for Treating End-Stage Liver Disease
Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Transplantation of mesenchymal stem cells (MSCs) represents a novel therapeutic strategy for end-stage liver disease. However, the clinical application of MSCs is limited by challenges in their proliferation and procurement. In this study, we demonstrate that modified MSCs with Nestin overexpression can exhibit enhanced proliferation and migratory capabilities. A sufficient quantity of functional mitochondria is crucial for hepatocyte proliferation. Notably, Nestin overexpression improves the mitochondrial function of modified MSCs and facilitates hepatocyte proliferation through the transfer of mitochondria via tunneling nanotubes (TNTs). In Echinococcus multilocularis infection models, we observed that modified MSCs significantly enhanced hepatocyte proliferation and effectively reduced liver damage. Consequently, the transplantation of modified MSCs emerges as a potential therapeutic modality for the treatment of end-stage liver disease.
