A Study on Clinical Outcomes of Septic Shock Patients Receiving Intravenous Vitamin C

Background Sepsis is a severe condition resulting from a dysregulated immune response to infection, often leading to organ failure and high mortality rates. Septic shock, the most severe form, has a mortality rate of 25–40% despite standard treatments. Aim To evaluate the impact of intravenous vitamin C on improving clinical outcomes in septic shock patients. This study aims to assess the effectiveness of high-dose intravenous vitamin C as a supplementary therapy in patients with septic shock. Methods A prospective, interventional study was conducted on 50 septic shock patients in the critical care unit (CCU) of a multispecialty hospital in Hyderabad, India. Patients were randomly assigned to two groups: the test group received intravenous vitamin C, while the control group received standard care. Data collected included demographics, comorbidities, infection source, blood culture results, vasopressor use, length of CCU stay, and MAP levels. SOFA and APACHE II scores were calculated before and after treatment. Data analysis was done using Microsoft Excel and SPSS version 26. Results The test group showed improvement in clinical outcomes, including reduced 30-day mortality, better APACHE II and SOFA scores, shorter ICU stays, and decreased vasopressor duration compared to the control group. Conclusion Intravenous vitamin C may help resolve septic shock more rapidly. However, due to the study’s small sample size and short duration, further research is needed to confirm the benefits of vitamin C in managing septic shock.