Investigation and analysis of life-related factors affecting the occurrence of colorectal adenomas and initial stages of colorectal cancer

OBJECTIVE: To investigate the effects of different lifestyle habits on the occurrence of different types of colorectal adenomas and their initial stages of cancer. Methods: 276 patients with colorectal tubular adenomas, 67 patients with colorectal serrated adenomas, and 70 patients with colorectal tubular adenomas with high-grade intraepithelial neoplasia, and 194 patients(control group ) underwent colonoscopy and were confirmed by pathology in the First Affiliated Hospital of Dalian Medical University during June 2023-December 2023. Lifestyle habits’ information was collected by questionnaire. RESULTS: Males had a higher risk of developing colorectal tubular adenomas than females (OR 2.705, 95% CI 1.654, 4.426), P<0.001, whereas colorectal tubular adenomas evolving into high-grade intraepithelial neoplasia had no statistically difference (P>0.05). Smoking increased the risk of colorectal serrated adenoma development (OR 2.38, 95% CI 1.136, 4.984), P=0.022. Alcohol consumption raised the risk of colorectal tubular adenoma development (OR 1.447, 95% CI 1.033, 2.026) and it evolving to high-grade intraepithelial neoplasia (OR 1.75, 95% CI 1.257, 2.436). Chronic sleep duration of less than 6 hours per night increased the risk of developing colorectal tubular adenomas (OR 2.501, 95% CI 1.333, 4.692), P=0.004. Hypertension increased the risk of colorectal tubular adenomas evolving into high-grade intraepithelial neoplasia(OR 1.879, 95% CI 1.033, 3.417), P=0.039. CONCLUSION: Males have a higher risk of developing colorectal tubular adenomas than females. Alcohol consumption and chronic sleep deprivation increase the risk of colorectal tubular adenoma development. Alcohol consumption and hypertension escalates the risk of initial-stage carcinoma of tubular adenoma. Smoking escalates the risk of developing serrated adenomas.