A Zea mays alanyl-tRNA synthetase mutant is seedling-lethal and suggests a retrograde signal from plastid rrn16 leader derived lncRNAs
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[120 words] A predicted retrograde signal for photomorphogenesis appears conserved with humans: organellar-homologous rRNA fragments mapping to mis-regulated long non-coding nuclear and/or mitochondrial pseudogene transcripts. Systems analysis of a maize virescent mutant for a plastid-localized ala-tRNA synthetase suggests histone genes as a novel retrograde signaling target in addition to other photobleaching-affected processes like Fe chelator transporters, terpene/chlorophyll and tetrapyrrole biosynthesis, glutathionylation, amino acid catabolism for energy, vesicle trafficking, and TORC/abiotic energy stress effectors. We speculate that deranged polyadenylation as an extreme photobleaching response associated with degradation of the retrograde signal might account for an observed bias in the most highly expressed nuclear genes: up typically in chlorotic photosynthetic mutants versus abnormally extreme bias for down-regulation of those genes in null albino mutants. Main Text [ 2170 words ]
