Effect of Computer-based Cognitive Remediation Therapy on Neurocognitive Functioning of Patient with Schizophrenia

Introduction: Schizophrenia patients often suffer from cognitive impairments that affect their social and occupational functioning. Computer-based cognitive remediation therapy (CCRT) has shown potential in improving neurocognitive function. This study evaluated the effectiveness of CCRT in improving neurocognitive function in schizophrenia patients. Methods: In this study, ten individuals diagnosed with schizophrenia and aged between 30 and 50, hospitalized for minimum six months and had up to eighth-grade education, were included. Neurocognitive assessments using the NIMHANS Neurocognitive Battery were conducted at baseline and after the intervention. CCRT sessions conducted twice weekly for six months alongside standard treatment. Results: Neurocognitive function improved significantly: mental speed by 36%, focused attention by 17.93%, sustained attention by 59.24%, response inhibition by 82.76%, comprehension by 42.99%, verbal learning by 193.62%, immediate recall of logical memory by 66.83%, and delayed recall by 50.23%. Effect sizes suggested clinically significant changes across domains, with a positive correlation between CCRT session quantity and cognitive functioning. Conclusion: These findings indicate CCRT as a promising intervention for enhancing cognitive function in schizophrenia patients. The significant improvements in multiple cognitive domains highlight its potential. Further research with larger samples and longer follow-up periods is required to validate these results and optimize CCRT protocols.